Herbert W. “Skip” Virgin, Washington University, USA
We study the equilibrium between virus and host using genetic, computational, sequencing, and structural approaches to test hypotheses. We focus on host pathways that are important for human disease susceptibility such as autophagy and interferon responses. Recent work has contributed to defining the mammalian virome, demonstrating immunologic and disease-related effects of the virome, and characterizing trans-kingdom interactions that control the virome. We have found that the virome can control the level of innate immunity, discovered a relationship between the virome and human inflammatory bowel disease, and have identified cytokine-dependent interactions between bacteria and helminths and control chronic viral infection.
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